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1.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson, Eachan O; LaVerriere, Emily; Office, Emma; Stanley, Mary; Meyer, Elisabeth; Kawate, Tomohiko; Gomez, James E; Audette, Rebecca E; Bandyopadhyay, Nirmalya; Betancourt, Natalia; Delano, Kayla; Da Silva, Israel; Davis, Joshua; Gallo, Christina; Gardner, Michelle; Golas, Aaron J; Guinn, Kristine M; Kennedy, Sofia; Korn, Rebecca; McConnell, Jennifer A; Moss, Caitlin E; Murphy, Kenan C; Nietupski, Raymond M; Papavinasasundaram, Kadamba G; Pinkham, Jessica T; Pino, Paula A; Proulx, Megan K; Ruecker, Nadine; Song, Naomi; Thompson, Matthew; Trujillo, Carolina; Wakabayashi, Shoko; Wallach, Joshua B; Watson, Christopher; Ioerger, Thomas R; Lander, Eric S; Hubbard, Brian K; Serrano-Wu, Michael H; Ehrt, Sabine; Fitzgerald, Michael; Rubin, Eric J; Sassetti, Christopher M; Schnappinger, Dirk; Hung, Deborah T.

Nature; 571(7763): 72-78, 2019 07.

Artículo en Inglés | MEDLINE | ID: mdl-31217586

2.

Chemical-genetic interaction mapping links carbon metabolism and cell wall structure to tuberculosis drug efficacy.

Koh, Eun-Ik; Oluoch, Peter O; Ruecker, Nadine; Proulx, Megan K; Soni, Vijay; Murphy, Kenan C; Papavinasasundaram, Kadamba; Reames, Charlotte J; Trujillo, Carolina; Zaveri, Anisha; Zimmerman, Matthew D; Aslebagh, Roshanak; Baker, Richard E; Shaffer, Scott A; Guinn, Kristine M; Fitzgerald, Michael; Dartois, Véronique; Ehrt, Sabine; Hung, Deborah T; Ioerger, Thomas R; Rubin, Eric J; Rhee, Kyu Y; Schnappinger, Dirk; Sassetti, Christopher M.

Proc Natl Acad Sci U S A; 119(15): e2201632119, 2022 04 12.

Artículo en Inglés | MEDLINE | ID: mdl-35380903

3.

The NLRP12 inflammasome recognizes Yersinia pestis.

Vladimer, Gregory I; Weng, Dan; Paquette, Sara W Montminy; Vanaja, Sivapriya Kailasan; Rathinam, Vijay A K; Aune, Marie Hjelmseth; Conlon, Joseph E; Burbage, Joseph J; Proulx, Megan K; Liu, Qin; Reed, George; Mecsas, Joan C; Iwakura, Yoichiro; Bertin, John; Goguen, Jon D; Fitzgerald, Katherine A; Lien, Egil.

Immunity; 37(1): 96-107, 2012 Jul 27.

Artículo en Inglés | MEDLINE | ID: mdl-22840842

4.

Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach.

Pulsifer, Amanda R; Vashishta, Aruna; Reeves, Shane A; Wolfe, Jennifer K; Palace, Samantha G; Proulx, Megan K; Goguen, Jon; Bodduluri, Sobha R; Haribabu, Bodduluri; Uriarte, Silvia M; Lawrenz, Matthew B.

Infect Immun; 88(3)2020 02 20.

Artículo en Inglés | MEDLINE | ID: mdl-31871100

5.

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.

Palace, Samantha G; Proulx, Megan K; Szabady, Rose L; Goguen, Jon D.

Infect Immun; 86(9)2018 09.

Artículo en Inglés | MEDLINE | ID: mdl-29891548

6.

The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.

Ratner, Dmitry; Orning, M Pontus A; Proulx, Megan K; Wang, Donghai; Gavrilin, Mikhail A; Wewers, Mark D; Alnemri, Emad S; Johnson, Peter F; Lee, Bettina; Mecsas, Joan; Kayagaki, Nobuhiko; Goguen, Jon D; Lien, Egil.

PLoS Pathog; 12(12): e1006035, 2016 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-27911947

7.

Manipulation of Interleukin-1ß and Interleukin-18 Production by Yersinia pestis Effectors YopJ and YopM and Redundant Impact on Virulence.

Ratner, Dmitry; Orning, M Pontus A; Starheim, Kristian K; Marty-Roix, Robyn; Proulx, Megan K; Goguen, Jon D; Lien, Egil.

J Biol Chem; 291(19): 9894-905, 2016 May 06.

Artículo en Inglés | MEDLINE | ID: mdl-26884330

8.

Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death.

Weng, Dan; Marty-Roix, Robyn; Ganesan, Sandhya; Proulx, Megan K; Vladimer, Gregory I; Kaiser, William J; Mocarski, Edward S; Pouliot, Kimberly; Chan, Francis Ka-Ming; Kelliher, Michelle A; Harris, Phillip A; Bertin, John; Gough, Peter J; Shayakhmetov, Dmitry M; Goguen, Jon D; Fitzgerald, Katherine A; Silverman, Neal; Lien, Egil.

Proc Natl Acad Sci U S A; 111(20): 7391-6, 2014 May 20.

Artículo en Inglés | MEDLINE | ID: mdl-24799678

9.

Reversion From Methicillin Susceptibility to Methicillin Resistance in Staphylococcus aureus During Treatment of Bacteremia.

Proulx, Megan K; Palace, Samantha G; Gandra, Sumanth; Torres, Brenda; Weir, Susan; Stiles, Tracy; Ellison, Richard T; Goguen, Jon D.

J Infect Dis; 213(6): 1041-8, 2016 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-26503983

10.

Manipulation of interleukin-1ß and interleukin-18 production by Yersinia pestis effectors YopJ and YopM and redundant impact on virulence.

Ratner, Dmitry; Orning, M Pontus A; Starheim, Kristian K; Marty-Roix, Robyn; Proulx, Megan K; Goguen, Jon D; Lien, Egil.

J Biol Chem; 291(31): 16417, 2016 07 29.

Artículo en Inglés | MEDLINE | ID: mdl-27474778

11.

Reply to Gelfand and Cleveland.

Proulx, Megan K; Ellison, Richard T; Goguen, Jon D.

J Infect Dis; 213(10): 1671-2, 2016 May 15.

Artículo en Inglés | MEDLINE | ID: mdl-26962234

12.

Host-pathogen genetic interactions underlie tuberculosis susceptibility in genetically diverse mice.

Smith, Clare M; Baker, Richard E; Proulx, Megan K; Mishra, Bibhuti B; Long, Jarukit E; Park, Sae Woong; Lee, Ha-Na; Kiritsy, Michael C; Bellerose, Michelle M; Olive, Andrew J; Murphy, Kenan C; Papavinasasundaram, Kadamba; Boehm, Frederick J; Reames, Charlotte J; Meade, Rachel K; Hampton, Brea K; Linnertz, Colton L; Shaw, Ginger D; Hock, Pablo; Bell, Timothy A; Ehrt, Sabine; Schnappinger, Dirk; Pardo-Manuel de Villena, Fernando; Ferris, Martin T; Ioerger, Thomas R; Sassetti, Christopher M.

Elife; 112022 02 03.

Artículo en Inglés | MEDLINE | ID: mdl-35112666

13.

Yersinia pestis escapes entrapment in thrombi by targeting platelet function.

Palace, Samantha G; Vitseva, Olga; Proulx, Megan K; Freedman, Jane E; Goguen, Jon D; Koupenova, Milka.

J Thromb Haemost; 18(12): 3236-3248, 2020 12.

Artículo en Inglés | MEDLINE | ID: mdl-33470041

14.

Distinct Bacterial Pathways Influence the Efficacy of Antibiotics against Mycobacterium tuberculosis.

Bellerose, Michelle M; Proulx, Megan K; Smith, Clare M; Baker, Richard E; Ioerger, Thomas R; Sassetti, Christopher M.

mSystems; 5(4)2020 Aug 04.

Artículo en Inglés | MEDLINE | ID: mdl-32753506

15.

Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice.

Smith, Clare M; Proulx, Megan K; Lai, Rocky; Kiritsy, Michael C; Bell, Timothy A; Hock, Pablo; Pardo-Manuel de Villena, Fernando; Ferris, Martin T; Baker, Richard E; Behar, Samuel M; Sassetti, Christopher M.

mBio; 10(6)2019 11 26.

Artículo en Inglés | MEDLINE | ID: mdl-31772048

16.

Common Variants in the Glycerol Kinase Gene Reduce Tuberculosis Drug Efficacy.

Bellerose, Michelle M; Baek, Seung-Hun; Huang, Chuan-Chin; Moss, Caitlin E; Koh, Eun-Ik; Proulx, Megan K; Smith, Clare M; Baker, Richard E; Lee, Jong Seok; Eum, Seokyong; Shin, Sung Jae; Cho, Sang-Nae; Murray, Megan; Sassetti, Christopher M.

mBio; 10(4)2019 07 30.

Artículo en Inglés | MEDLINE | ID: mdl-31363023

17.

Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype.

Smith, Clare M; Proulx, Megan K; Olive, Andrew J; Laddy, Dominick; Mishra, Bibhuti B; Moss, Caitlin; Gutierrez, Nuria Martinez; Bellerose, Michelle M; Barreira-Silva, Palmira; Phuah, Jia Yao; Baker, Richard E; Behar, Samuel M; Kornfeld, Hardy; Evans, Thomas G; Beamer, Gillian; Sassetti, Christopher M.

mBio; 7(5)2016 09 20.

Artículo en Inglés | MEDLINE | ID: mdl-27651361

18.

Genome-wide mutant fitness profiling identifies nutritional requirements for optimal growth of Yersinia pestis in deep tissue.

Palace, Samantha G; Proulx, Megan K; Lu, Shan; Baker, Richard E; Goguen, Jon D.

mBio; 5(4)2014 Aug 19.

Artículo en Inglés | MEDLINE | ID: mdl-25139902

19.

Fibrin microthreads support mesenchymal stem cell growth while maintaining differentiation potential.

Proulx, Megan K; Carey, Shawn P; Ditroia, Lisa M; Jones, Craig M; Fakharzadeh, Michael; Guyette, Jacques P; Clement, Amanda L; Orr, Robert G; Rolle, Marsha W; Pins, George D; Gaudette, Glenn R.

J Biomed Mater Res A; 96(2): 301-12, 2011 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-21171149

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